A unique position to meet patient needs

  • Our comprehensive portfolio of treatment options allows the patient and physician to choose the best method of administration
  • A lean operating model delivers profitability while we continue to invest in advancements in innovation and operations
  • Investments in research validate the value propositions of our products in the marketplace
  • Continuous improvement in operations ensures we can provide the right product to the right patient on time, every time

Market environment

Allergic diseases: allergies on the rise

Today, more than one billion people worldwide are affected by allergies. The number of people who suffer from allergies has risen continuously over the past 60 years, with higher incidence rates among children. By 2050, it is expected that 1 out of 2 people across the globe will suffer from allergies1

A rapidly increasing prevalence

The increasing prevalence and intensity of allergies is a trend that has continued in the industrialised world for more than 60 years. Allergies currently affect over 13% of the world’s population, and an estimated 20 to 30% of the developed world. This trend is associated with urbanisation and changes in lifestyle, such as modern hygiene standards and reduced microbial exposure, as well as changing dietary habits. As these factors develop, allergies are expected to impact up to four billion people over the next three decades2 .

Too many patients don’t get therapy

Allergic rhinitis affects approximately 10% to 30% of adults and 40% of children3. Only approximately 12% of people suffering from allergic rhinitis are treated with allergy immunotherapy (AIT) products due to low awareness among primary care prescribers, a complex treatment pathway and a market that is dominated by lower cost symptomatic treatments. AIT addresses the underlying cause of allergy and may provide both quick and long-lasting improvement of all symptoms, whereas symptomatic treatments (such as antihistamines and corticosteroids) temporarily relieve some allergy symptoms.

With a modest proposal rate, the AIT market is still underdeveloped, representing approximately €1bn or 12% of the global allergic rhinitis market, and is expected to grow by 2% annually in the coming years4.. The market growth is expected to result from an increased awareness of respiratory allergies, a simplified access to allergists, the expanded range of administration modes as well as a growing middle class in developing countries that will gain access to medical treatment.

Innovation in science and technology is creating new medical opportunities

Biologics, gene therapies and other new molecularly targeted compositions are starting to deliver on their promise to enable more precise diagnostics and tailored treatments. The development of more patient-friendly treatments (shorter treatment lengths, ease of use) should improve AIT penetration in the allergic rhinitis patient population and its adherence.

In addition, advances in the areas of genetics and informatics are driving a transformation in our understanding of the disease. Innovations in technology also present opportunities to more efficiently and effectively address the growing volume of regulatory requirements, particularly regarding more stringent manufacturing requirements.

Rise in allergies gaining attention from payers, providers and regulators

As more patients seek treatment for their allergies, the AIT industry has gained greater attention from the healthcare community. Healthcare providers are seeking more clinical evidence related to the safety and efficacy of AIT; payers are more tightly controlling access and increasingly requiring data about the economic benefit to maintain coverage for treatment; and regulatory bodies are increasing their scrutiny and enacting more stringent requirements of biologics manufacturers.


1. WAO Ambient air pollution Health impact

2.3.4.  World Allergy Organization)




Pollution and climate change >

The number of people affected by respiratory allergies and asthma has been increasing steadily for decades, in both industrialised and nonindustrialised countries, due to changes in our environment. The quality of the air we breathe has become an important concern for public health authorities around the world.

Motor vehicle emissions and increased urbanisation are linked to the rising prevalence of pollen-induced respiratory allergies. Observational evidence indicates that recent regional changes in climate, particularly temperature increases, have already affected a diverse set of physical and biological systems in many parts of the world. Climate change is also affecting allergen patterns and air pollution can modify the allergenic potential of pollens especially in presence of specific weather conditions.

The consequences on health vary from decreases in lung function to allergic diseases, new onset of diseases, and exacerbation of chronic respiratory diseases1 


1. D’Amato G, Liccardi G, D’Amato M. The role of outdoor air pollution and climatic changes on the rising trends in respiratory allergy



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